main problemthe main problem is low response rate.
have a problemWhich I don't have a problem with.
only problemThe only problem is that it now takes a baffling turn.
major problemActomite is the new solution to a major problem.
serious problemBut there is a serious problem here.
problem hereBut there is a serious problem here.
real problemCost-saving exercises may not be tackling the real problem which is the need for a structural change.
solve the problemPressure on East Germany to solve the problem of its fleeing population by reform has redoubled.
particular problemIt is a particular problem in the south-east, where there are escalating costs.
second problemA second problem centred on the sessions provided by non-nurse speakers.